Published Scientific Studies
Human Health
Formaldehyde as a Potential Human Leukemogen: An Assessment of Biological Plausibility; Golden, Pyatt and Shields; Critical Reviews in Toxicology; April 2006
http://journalsonline.tandf.co.uk/(2hetg545fv3orj551yi1s045)/app/home/ contribution.asp?referrer=parent&backto=issue,2,4;journal,3,50; linkingpublicationresults,1:104774,1;
The implausibility of leukemia induction by formaldehyde: a critical review of the biological evidence on distant-site toxicity; Heck and Cassanova; Regulatory Toxicology and Pharmacology; June 2004
http://www.elsevier.com/wps/find/journaldescription.cws_home/622939/ description#description HOME PAGE ONLY
Extended Follow-Up of a Cohort of British Chemical Workers Exposed to Formaldehyde; Coggon, Harris, Poole and Palmer; Journal of the National Cancer Institute
http://jncicancerspectrum.oxfordjournals.org/cgi/content/ abstract/jnci;95/21/1608?fulltext=Formaldehyde&searchid=QID_NOT_SET
Reevaluation of mortality risks from nasopharyngeal cancer in the formaldehyde cohort study of the National Cancer Institute; Marsh and Youk; Regulatory Toxicology and Pharmacology; June 2005
http://www.elsevier.com/wps/find/journaldescription.cws_home/ 622939/description#description HOME PAGE ONLY
Reevaluation of mortality risks from leukemia in the formaldehyde cohort study of the National Cancer Institute; Marsh and Youk; Regulatory Toxicology and Pharmacology; June 2004
http://www.elsevier.com/wps/find/journaldescription.cws_home/ 622939/description#description HOME PAGE ONLY
A review and meta-analysis of formaldehyde exposure and leukemia; Collins and Lineker; Regulatory Toxicology and Pharmacology; June 2004
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Formaldehyde and leukemia: an improbable causal relationship; Cole and Axten; Regulatory Toxicology and Pharmacology; July 2004
http://www.elsevier.com/wps/find/journaldescription.cws_home/ 622939/description#description HOME PAGE ONLY
Mortality From Lymphohematopoietic Malignancies Among Workers in Formaldehyde Intustries; Hauptmann, Lubin, Stewart, Hayes and Blair, Journal of the National Cancer Institute, Nov. 5, 2003
http://jncicancerspectrum.oxfordjournals.org/cgi/content/ abstract/jnci;95/21/1615?fulltext=Formaldehyde&searchid=QID_NOT_SET
Mortality from Solid Cancers among Workers in Formaldehyde Industries; Hauptmann, Lubin, Stewart, Hayes and Blair, American Journal of Epidemiology, March 2004
http://aje.oxfordjournals.org/cgi/ content/abstract/159/12/1117
Formaldehyde-induced gene expression in F344 rat nasal respiratory epithelium; Hester, Benavides, Yoon, Morgan, Zou, Barry and Wolf, Toxicology, January 2003
Inhaled formaldehyde: Evaluation of sensory irritation in relation to carcinogenicity: Arts, Rennen and de Heer, Regulatory Toxicology and Pharmacology, January 2006
http://www.elsevier.com/wps/find/journaldescription.cws_home/ 622939/description#description HOME PAGE ONLY
CIIT Centers for Health Research, Formaldehyde: Hazard characterization and dose-response assessment for carcinogenicity by the route of inhalation (revised ed. 1999) (full report available from CIIT or EPA IRIS docket; Executive Summary available at http://www.ciit.org/newsrs/formaldehydesummary. CIIT receives funding from the chemical industry generally, but FETEG did not provide any funding for the risk assessment project.
FormaCare, Scientific Fact Sheet – Formaldehyde: http://www.formaldehyde-europe.org/ pages/%20scientific_fact_sheet.scientificfactsheet.0.html
Bender, Joel, The Use of Noncancer Endpoints as a Basis for Establishing a Reference Concentration for Formaldehyde, Regulatory Toxicology and Pharmacology 35:23, 30; Feb. 2002
http://www.elsevier.com/wps/find/journaldescription.cws_home/ 622939/description#description HOME PAGE ONLY
National Academy of Sciences, Institute of Medicine; Clearing the Air: Asthma and Indoor Air Exposures, at 246 (2000); available at http://www.formaldehyde-europe.org/ pages/%20scientific_fact_sheet.scientificfactsheet.0.html.
Pinkerton LE, Hein MJ, Stayner LT, 2004. Mortality among a cohort of garment workers exposed to formaldehyde: an update. Occup. Environ. Med. 61: 193-200.
http://www.joem.org/pt/re/joem/home.htm; jsessionid=EhJj BcwIdJkPmRfJhI9vkentjrj1zheKPURmzbeT6uM6NA962wmu! -839643570 !-949856144!9001!-1 HOME PAGE ONLY
Marsh GM, Youk AO, Buchanich JM, Cassidy LD, Lucas LJ, Esmen NA, Bathau IM, 2003. Pharyngeal cancer mortality among chemical plant workers exposed to formaldehyde. Toxicology and Industrial Health; 12: 257-268.
http://www.ingentaconnect.com/content/arn/tih HOME PAGE ONLY
Collins J, 2004. Formaldehdye exposure and leukemia. Occupational and Environmental Medicine; 61: 875-876.
http://www.joem.org/pt/re/joem/ home.htm;jsessionid= EhJjBcwIdJkPmRfJhI9vkentjrj1zheKPURmzbeT6uM6NA962wmu! -839643570!-949856144!9001!-1 HOME PAGE ONLY
Burgaz S, Cakmak G, Erdem O, Yilmaz M, Karakaya AE, 2001. Micronuclei frequencies in exfoliated nasal mucosa cells from pathology and anatomy laboratory workers exposed to formaldehyde. Neoplasia 48: 144-147.
Casanova M, Heck HD’A, 1987. Further studies of the metabolic incorporation and covalent binding of inhaled [3H-]- and [14C]formaldehyde in Fischer-344 rats: effects of glutathione depletion; Toxicology and Applied Pharmacology; 89: 105-124.
http://www.sciencedirect.com/science?_ob= ArticleURL&_udi=B6WXH-4DD30C0-DX&_user=10& _handle=V-WA-A-W-AY-MsSAYWA-UUW-U-AAVEDCUWYD- AAVDBBAUYD-YCCDCZVZD-AY-U &_fmt=full&_coverDate=06%2F15%2F1987 &_rdoc=12&_orig= browse&_srch=%23toc%237159%231987%23999109998%23520953! &_cdi=7159&view=c&_acct=C000050221&_version=1&_urlVersion=0& _userid=10 &md5=f16c670f46e21ad4d390f177921f3a09
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Comprehensive Reviews
Concise International Chemical Assessment Document 40, FORMALDEHYDE; World Health Organization, 2002
German MAK Commission, 02/24/2000
Developmental & Reproductive Toxicity
James J. Collins et al., A Review of Adverse Pregnancy Outcomes and Formaldehyde Exposure in Human and Animal Studies, Regulatory Toxicology and Pharmacology 34 :17, 31 (2001).
http://www.elsevier.com/wps/find/journaldescription.cws_home/ 622939/description#description HOME PAGE ONLY
Formaldehyde as a Naturally Occurring Compound
Concise International Chemical Assessment Document 40, FORMALDEHYDE; World Health Organization, 2002
Genotoxicity
German MAK Commission
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve& db=PubMed&list_uids=12676450&dopt=Abstract
Bolt HM, 2003. Genotoxicity – threshold or not? Introduction of cases of industrial chemicals. Toxicol. Lett. 140-141: 43-51.
http://www.elsevier.com/wps/find/journaldescription.cws_home/ 505519/description#description HOME PAGE ONLY
Indoor Air
Formaldehyde and TVOC Emissions from Thermal Insulation Products; Lawrence, Axton and Black
Formaldehyde Emissions from Thermal Insulation Products; Axten and Tannous;
Maximum exposure levels for xylene, formaldehyde, and acetaldehyde in cars; Schupp, Bolt and Hengstler, Toxicology, August 2004
Opinion on the Report: "Emission of chemicals by air fresheners Tests on 74 consumer products sold in Europe;" Scientific Committee on Health and Environmental Risks (SCHER), EUROPEAN COMMISSION, Health & Consumer Protection Directorate-General, Jan. 2005
Daniel A. Hare et al., Evaluating the Contribution of UF-Bonded Building Materials to Indoor Formaldehyde Levels in a Newly Constructed House, at 19 (1996) (presented at 30th Annual Particle Board/ Composite Materials Symposium in Pullman, Washington; full report available from Composite Panel Association). See also M. Koontz et al., Residential Indoor Air Formaldehyde Testing Program: Pilot Study (prepared for U.S. EPA, Office of Pollution Prevention and Toxics) (1996).
Inhalation Studies
German MAK Commission
A mathematical model for the absorption and metabolism of formaldehyde vapour by humans; Franks, Toxicology and Applied Pharmacology, Nov. 2004
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXH- 4DD30C0-DX&_user=10&_handle=V-WA-A-W-AY-MsSAYWA- UUW-U-AAVEDCUWYD-AAVDBBAUYD-YCCDCZVZD-AY-U& _fmt=full&_coverDate=06%2F15%2F1987&_rdoc=12&_orig=browse& _srch=%23toc%237159%231987%23999109998%23520953! &_cdi=7159&view=c& _acct=C000050221&_version=1&_urlVersion=0 &_userid=10&md5=f16c670f46e21ad4d390f177921f3a09
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Neurotoxicity
Occupational Exposure
Dennis Paustenbach et al., A Recommended Occupational Exposure Limit for Formaldehyde Based on Irritation, Journal of Toxicology and Environmental Health 50:217, 220 (1997).
http://taylorandfrancis.metapress.com/(uyullf45yupb3tvrukzhhi45)/ app/home/contribution.asp?referrer=parent&backto=issue,2,5; journal,181,201;linkingpublicationresults,1:100675,1
ABSTRACT
Sensory Irritation
Skin Sensitization
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